Create a empty spreadsheet in google drive using google spreadsheet api (python )?

You can do this using the Drive API by setting the MIME type to application/vnd.google-apps.spreadsheet:

To do this in Python:

from apiclient.discovery import build
service = build('drive', 'v2')

import httplib2
credentials = ... # Obtain OAuth 2.0 credentials
http = credentials.authorize(httplib2.Http())

body = {
  'mimeType': 'application/vnd.google-apps.spreadsheet',
  'title': 'Name of Spreadsheet',
}
file = service.files().insert(body=body).execute(http=http)

Head over to the Google APIs Explorer to try it out!