File "profiling\tracing\timers.py", line 24, in Timer
    clock = time.clock
AttributeError: module 'time' has no attribute 'clock'

Seems need change function clock on time.perf_counter() or time.process_time()

https://github.com/brendangregg/FlameGraph

Currently, the timings on node labels are shown like this: 0.1234

It's not immediately clear that that's in seconds. Can we add a " s" to the label? Or maybe even consider changing it to milliseconds and adding " ms".

I'm not familiar with all the input formats and if they have the timing information in seconds or not, but if it's just a matter of changing the label formatting, I'm happy t

Aggregating keys by pattern and type
Traceback (most recent call last):
  File "/home/ubuntu/.local/bin/rma", line 11, in <module>
    sys.exit(main())
  File "/home/ubuntu/.local/lib/python3.5/site-packages/rma/cli/rma_cli.py", line 97, in main
    app.run()
  File "/home/ubuntu/.local/lib/python3.5/site-packages/rma/application.py", line 133, in run
    keys = {k: self.get_pattern_ag

https://docs.google.com/document/d/1CvAClvFfyA5R-PhYUmn5OOQtYMH4h6I0nSsKchNAySU/preview

SQLAlchemy() allows construction without app set, waiting until a later init_app() call. We should test and document this case - it may mean instrument_sqlalchemy() shouldn't be called until after init_app().

https://flask-sqlalchemy.palletsprojects.com/en/2.x/api/#flask_sqlalchemy.SQLAlchemy

Specifically,

• VCF content requirements (is partly implicitly there; I was only missing allowable SV-types)
• how-to for bypassing SV-calling and inserting existing SV calls
• how-to (sketch) for adding a new feature,
• rebalancing an existing one (?)
• format of the internal files (.txt) - compatible with other signature tools?
• runtime guesstimates

We plan to make a better documentation.